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Dehydration itself trended toward a significant increase in the semaglutide trials (RR 2.16, p = 0.071)
PATHOPHYSIOLOGY OF DKD Mechanisms of action SGLT2 inhibitors primarily act by blocking SGLT2 located on the luminal membranes of proximal renal tubules (S1 and S2 segments)
Second, we have to consider the downstream metabolic consequences
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