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Surprisingly, PAR2-R38E mice showed reduced ghrelin levels in both sexes, indicating that an alternative protease, such as trypsin expressed by epithelial cells of the stomach (49), directly regulated ghrelin expression through PAR2 signaling (Figure 2O)
This was accompanied by improvements in multiple additional outcomes as reported in the publication
& Messer, A
Key drivers include: Increased FDA enforcement risk Narrower legal interpretations under the SAFE Drugs Act Reduced flexibility tied to drug shortages Direct enforcement by patent holders The possibility of injunctions that can halt operations overnight For many companies, the legal exposure now outweighs the potential revenue
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