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Furthermore, ongoing research and development activities would bring next-generation GLP-1 therapies, oral formulations, and dual incretin therapies

2020;92: e20200012

Its sequence AcNlecyclo[AspHisDPheArgTrpLys]NH incorporates a norleucine substitution, a Dphenylalanine substitution, and a lactam bridge that cyclises the molecule, conferring markedly greater stability and resistance to enzymatic degradation than the native linear hormone

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