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This distinction was explored in a study where the Ex4-induced decline in alcohol drinking was blunted in central GLP-1R knockout mice, whereas the effect of Ex4 remained intact after peripheral GLP-1R knockout (Figure 2) ( FIGURE 2 On this note, Ex4 introduction into the NTS lowers alcohol drinking in male rats ( via NTS to regulate alcohol responses

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Calcitonin receptor activation has been studied for its own effects on food intake and glucose handling, and some researchers argue that a balanced amylin/calcitonin profile produces stronger or more durable metabolic effects than amylin alone