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Dissociated TXNIP combines with and activates the NLRP3 inflammasome to induce IL-1 expression in a NLRP3-ASC-caspase-1-dependent manner, thus causing inflammatory reactions

Consistent with these findings, in vivo and in vitro experiments have demonstrated that Trx2 reduces myocardial ischemia-reperfusion injury by inhibiting ROS-mediated autophagy through the Akt/mTOR and AMPK/mTOR signaling pathways (144,145)