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And I was like, all right, look, dude

In cell and animal models, amino acid metabolism not only provides substrates for energy production and biosynthesis, but also regulates the differentiation of macrophages toward M1 or M2 phenotypes by modulating signaling pathways such as STAT1, mechanistic target of rapamycin (mTOR), and NF-B, as well as by affecting epigenetic regulation (59)

Nagatani et al

7.4 Improvement of translational and clinical research We also emphasize the importance of well-designed animal studies and clinical investigations to validate the safety, efficacy, and mechanisms of gutliver axistargeted interventions, thereby facilitating their potential translation into clinical applications