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The combination is often preferred for those focused on improving lean muscle mass and recovery
Weight gain despite reduced appetite on Rybelsus may result from fluid retention as blood glucose improves, constipation (a recognised side effect), metabolic adaptation to calorie restriction, interactions with other medications such as insulin or antidepressants, or hormonal factors
Discontinuing tirzepatide without a medical plan can lead to a return of previous symptoms or health issues, so we generally recommend continuing the medication as directed to sustain its benefits
Renal function monitoring at least annually , or more frequently in patients with pre-existing kidney disease or those experiencing significant gastrointestinal side effects
