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26,27 Drug Efficacy and Side Effects in Clinical Trials The first GLP-1RA that received FDA approval was put on the market in 2005 under the name exenatide
If the drugs are directly both improving weight reduction and cancer reduction, then we need to double down. Ganta wonders the same thing about the drugs apparent positive effects on several conditions, from dementia to sleep apnea: Is it that obesity is causing or contributing to the problem [and that weight loss is causing the improvement], or is the medication directly having an impact through a different mechanism? She hopes there will be more research to parse this out in the years to come
Summary of GLP-1 Mechanism: Stimulates insulin release , lowering blood sugar levels
The two most important incretin hormones responsible for this effect are glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide (GLP)-1
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