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Consistently, a large number of studies have previously suggested that the IGF system is involved in mammalian reproductive functions[108, 126, 127]

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highlight that this sequence incorporates several carefully designed amino acid substitutions that may support stability and resistance to enzymatic degradation: (1) At the second position, there is a substitution with D-alanine, possibly offering protection against rapid cleavage by dipeptidylpeptidase-IV (DPP-IV), a key enzyme involved in the degradation of endogenous GHRH