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While Phase II trials in heart failure and primary mitochondrial myopathy did not meet primary efficacy endpoints, the TAZPOWER trial in Barth syndrome demonstrated significant improvements in muscle strength and sixminute walk distance, leading to FDA accelerated approval in 2025 [3] [10]

This cascade then activates endothelial nitric oxide synthase through Ser1177 phosphorylation, generating the nitric oxide that drives vessel formation

In the AMY 3 R consensus maps, density allows potential modelling of an alternate rotamers of F23 Cagri in antiparallel with Y146 1.37 (Supplementary Fig

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