Proc Natl Acad Sci U S A 99:1190813 Harvey CJ, Thimmulappa RK, Singh A, Blake DJ, Ling G, Wakabayashi N, Fujii J, Myers A, Biswal S (2009) Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress
In vitro stability assay with high glutathione concentration GLP-1MK-801 was dissolved in dimethyl sulfoxide at a concentration of 0.25 mM and diluted with a solution of 200 mM glutathione in PBS, pH 7, such that the final concentration of GLP-1MK-801 in the assay was 100 M
The cellular uptake of the nanoparticles in 143B cells was investigated upon labeling of NP4 with the well-characterized dye Cy5.5 into the nanoparticle formulation NP4-Cy5.5
Unbound free iron leads to the formation of dangerous free radicals, which lead to lipid peroxidation