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Preclinical studies have also revealed that dual agonists of GLP-1R and glucose-dependent insulinotropic polypeptide receptor (GIPR) have synergistic anti-inflammatory and neuroprotective effects, suggesting the potential advantages of multitargeting strategies (Yuan et al., 2024)

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A procedure encompassing affinity purification and size exclusion chromatography was used to purify the tagged PDS5B to near homogeneity (Fig

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