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According to publicly disclosed topline results from the Phase 3 EVOKE and EVOKE+ programs data that are currently available only as preliminary announcements and have not yet been fully peer-reviewed or published the trials did not demonstrate clinical efficacy (Athauda et al., 2026)
GS had no effect on COX-1 mRNA expression in either the absence or presence of IL-1 (Figure 2A, 2B)
In the initial semaglutide weight loss trial, 14% of patients lost less than 5% of body weight and 31% lost less than 10%
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