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Its main function is supporting muscle growth and repair, so its a common choice for athletes when they want to give their bodies the best chance of bouncing back after a workout

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Given that ACLY cleaves citrate into oxaloacetate and acetyl-CoA, the increase in citrate and ACLY levels induced by trastuzumab could reflect: 1) a need for TCA cycle fueled energy through oxphos as well as 2) an alteration of lipid metabolism in trastuzumab resistant cells