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In the STEP-10 trial, over 40% of lost weight was regained within just 28 weeks of discontinuation
Toda T, Parylak SL, Linker SB, Gage FH
In hepatocellular carcinoma (HCC) studies, ADI-PEG-20 has been shown in early clinical trials to make HCC animal models and patients more sensitive to FOLFOX chemotherapy through arginine depletion
On the other hand, continuous mucin hypersecretion may reduce the quantity of goblet cells, which would destroy the mucus barrier ( 2.5 Ochratoxin (OTA) Studies conducted in vitro demonstrated that OTA reduced the SGLT1 transporters ability to absorb glucose (Peraica et al., 2011)
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