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A follow-up study demonstrated that AOD-9604 stimulated lipolysis and simultaneously inhibited lipogenesis in isolated adipocytes
The only requirement is that the drug gets delivered via the subcutaneous or intramuscular route, not intravenously
Mechanistically they do not overlap (GLP-1 agonists work through appetite and gastric emptying, this works on adipocyte lipogenesis and NAD+), and the mouse data specifically showed fat loss without reduced food intake, so they are not redundant
AOD-9604 is not FDA-approved for any therapeutic use
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