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Curcumin formulations with enhanced bioavailability are thought to achieve therapeutic concentrations in plasma, which can reach dermal tissues to exert antiaging effects, particularly relevant for women experiencing estrogen decline [64]
What you should not do is run it 7 days/week indefinitely the receptor desensitization issue still applies
Other groups including ICI, (later AstraZeneca), Abbott- Takeda and Hoechst AG, (later Aventis) also developed depot formulations of their respective LH-RH agonists, goserelin, leuprolide, and buserelin consisting of microcapsules or implants in poly (lactide-glycolide) or other polymers administered once a month 3
However, recent advances in the development of peptide-based drugs have led to improvements in peptide solubility and oral bioavailability for both linear and cyclic peptides, with several drugs being approved or entering clinical trials
