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In the GLP-1R:TT-OAD2 Gs complex (left), structural water molecules form stable hydrogen bonds with the N3205.50 side chain and the Y2413.44 backbone atoms as well with E3646.53
The limited availability of free CoA leads to the arrest of the beta-oxidation process and to the accumulation of harmful long-chain acylCoA and acylcarnitines in the mitochondria
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