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Many people improve with dietary changes alone, but others may need additional care

Jeffrey Singer of the Cato Institute also proposed that making these drugs available without a prescription might reduce cost, increase access, and decrease stigma, but this change would likely take many years and receive pushback from clinicians

Therefore, patients' liver function should be closely monitored, and patients who clearly respond to PN should continue with PN therapy, and the addition of the PNPO cofactor riboflavin may improve the activity of residual PNPO [14]