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[4] While common, it is important to note that these events are generally mildtomoderate, and they are also often transient, occurring most frequently during or shortly after dose escalation

However, since the tubular reabsorption occurs via an active transporter, once the transporter is saturated by the high plasma L-carnitine concentrations achieved by intravenous administration, the circulating L-carnitine is rapidly excreted

The favorable safety profile across dozens of clinical studies supports the use of NAD+ tablets in extended research protocols

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