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This postulation was later confirmed in a mouse model, where stimulation of GLP-1 receptors on atrial cells induced a chronotropic effect, but only when neuronal input was present (112)

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Whilst we found that ex vivo vehicle treated cells produced high levels of cytokines, including IL-5, IL-13, IL-9 ( Supplementary Figures 4BD ), and modest amounts of IL-10 and IL-6 ( Supplementary Figures 4E, F ), melatonin treatment greatly reduced the concentration of all cytokines analyzed ( Supplementary Figures 4B F )

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