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Table 3 summarizes the PIONEER trial programmes [35,36,37,38,39,40,41,42,43,44]

In addition, women in the treatment arm ( n = 85) were supplemented daily with 3 g of LC orally (day-3 until day of first positive pregnancy test), while those in the control arm (n = 85) received a placebo

Hypothalamus: appetite suppression via arcuate and paraventricular nucleus GLP-1R signaling, enhancing satiety and reducing food intake

In a study involving participants who followed their treatment, those on low dose semaglutide for maintenance still achieved significant reductions in body mass, reinforcing the value of personalized dosing strategies