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Are family physicians setting up patients for a lifetime of potentially unsafe treatment
Answer: Glucagon-like peptide-1 (GLP-1) receptor agonists, a class of medications that includes semaglutide (Wegovy, Ozempic, Rybelsus), tirzepatide (Zepbound, Mounjaro), liraglutide (Victoza, Saxenda), and orforglipron (Foundayo), have become increasingly popular for obesity treatment (Mehrtash, JAMA Intern Med 2025)
This is the most consistently reported side effect and tends to persist
100 Nitric oxide (NO) plays a crucial role in regulating vascular endothelial cell relaxation, maintaining stable renal vascular tone, and influencing renal blood flow, renin secretion, and tubuloglomerular feedback mechanisms
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