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The medication is absorbed directly into the bloodstream from subcutaneous tissue, making the presence or absence of food in the stomach clinically irrelevant to drug pharmacokinetics
Some protocols suggest holding the liquid in the mouth for 30-60 seconds before swallowing to allow for some initial absorption through the buccal mucosa (the lining of the mouth)
Semaglutide directly accessed the brainstem, septal nucleus, and hypothalamus but did not cross the blood-brain barrier
10.13294/j.aps.2022.0064 102 XiongY
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