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lysine decoration conferred a proton sponge effect that protected cargo from lysosomal degradation, while pH-triggered disassembly of the 4LF shell released saRNA into the cytoplasm to upregulate Sirt1

Exendin-4 could still exhibit stimulatory activity in the same setting, suggesting that either mTORC2 alone or both mTOR complexes must be blocked in order to completely abrogate GLP-1R signalling action on glycolysis

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