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Novel GLP-1R agonists currently under development include HRS9531, a dual GLP-1/GIP receptor agonist being evaluated in overweight or obese individuals with T2DM, which has shown promising results in a Phase 2 study [172]
Polyethylene glycol (PEG) precipitation The optimal concentration of PEG6000 for precipitating anti-semaglutide antibodies while minimizing precipitation of semaglutide and human serum albumin (HSA) was determined using a Gamma Counter Wizard 3470 (Perkin Elmer, Waltham, MA, USA) with the WorkOut Plus software
However, direct cardiovascular outcome evidence specifically demonstrating superiority over semaglutide is not yet established
For instance, the semaglutide for treatment of type 2 diabetes is Ozempic while the one approved for weight loss is Wegovy
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