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While topical application has minimal systemic absorption, the precautionary principle suggests avoiding use during pregnancy unless a healthcare provider approves
Compared to tablets, injections deliver the vitamin straight into the bloodstream
There, KPV inhibits the activation of NF-kB by delaying the turnover of NF-kB and IkBalpha, and it additionally suppresses the phosphorylation of MAPK, namely ERK1/2, JNK and p38
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