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(Read about TNF genes) IL-1 decreases neurogenesis via the kynurenine pathway.[ref] (read about kynurenine genes) Inflammation decreases the synthesis of neurotransmitters through the disruption of BH4, which is needed for dopamine and serotonin synthesis.[ref] (Read about BH4 genes) TNF-alpha and IL-1 increase the reuptake of serotonin, leaving less serotonin available.[ref] (read about serotonin genes) Increased inflammation shifts the body from converting tryptophan into serotonin and instead produces kynurenine, which has a neurotoxic metabolite called quinolinic acid

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Conversely, CKD may also induce oxidative damage in other pathological conditions [308, 318, 319]