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For the minority of MM patients with BRAF mutations, combined inhibition of BRAF and MEK is an attractive strategy because the combination therapy shows an impressive response rate at 76% and has a 5-year survival rate of 33% for BRAFV600E/K positive CM patients ( BRAF mutations but with NRAS , NF1 , or SPRED1 alterations, targeting the downstream protein MEK is another strategy for MM patients
Combining Mounjaro with medications like insulin may increase the risk of low blood sugar, while other drugs could interfere with its effectiveness
2023 Jan;39(1):171-213
reports personal fees from Aetion Inc., a software-enabled analytics company, and grants from Bayer, UCB and Boehringer Ingelheim to Brigham and Womens Hospital outside the submitted work
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