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doi: 10.1016/j.ejphar.2007.05.072

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In particular, this variant produces an altered fixation of SP1 and PC4 transcription factors in the promoter, resulting in a decreased transcription activity ( MET gene can also be regulated by FOXP2 and MeCP2, which are both factors that affect ASD-related circuit development in humans ( FIGURE 3 Furthermore, MET levels in post-mortem temporal lobe samples of autistic or healthy individuals were analyzed in other studies, showing a reduction in MET transcripts and proteins in patients with ASD compared to control ones (Figure 3)