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Pre-treatment protocol: Combine pre-injection antihistamine (1 hour before) with pre-injection ice (30 to 60 seconds before) and post-injection cold compress (10 to 15 minutes after) for maximum prevention
C.ChangS
Presented for research literature review only Mercurio L et al
The consequence is that we cannot confidently answer basic clinical questions: What is the maximum tolerated dose in humans
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