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They're trending towards the sustained decline, and that decline starts to rewire metabolic physiology in several ways

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These treatment conditions were chosen to mimic excess heme from chronic hemolysis and systemic hypoxic conditions that occur in SCD patients 1,2,11

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A series of PA concentrations (0.125, 0.25 and 0.5 mmol/L) were used for 24 h incubation to induce endothelial dysfunction

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