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We engrafted the nine C-terminal residues onto the C-terminal end of xGLP to increase the potency toward GLP1R
Tumour volumes were calculated by measuring two perpendicular diameters with calipers and using the formula: tumour volume=(length width 2 )/2
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While older medications target only one gut hormone, tirzepatide mimics two distinct, naturally occurring incretin hormones in the human body: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)
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