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A standard 16-week protocol following the 2mg, 4mg, 8mg, 12mg escalation requires approximately 104mg total

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Acknowledgments The authors are grateful to Dyanne Brewer and Armen Charchoglyan at the mass spectrometry facility within the University of Guelphs Advanced Analysis Centre for technical assistance with the HPLC-MS/MS analysis

Extending a cycle just because the calendar has not ended can make the plan harder to judge