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Tirzepatide Efficacy: The SURMOUNT-1 trial showed that participants on the highest 15 mg dose achieved a mean weight reduction of 22.5% after 72 weeks
The available ESSENCE publication does not include individual participant data (IPD), multivariable models that adjust for weight loss, or mediation analyses to estimate effects independently of body weight or other metabolic variables [7]
Metabolic and hormonal improvements associated with weight loss often enhance fertility, particularly in individuals with obesity
Some patients remain symptom-free from day one, while others experience mild effects for up to six weeksindividual timelines vary significantly
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