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This approach has three advantages: First, it establishes a hormonal baseline
This underscores a CDMO strategy: leveraging a broad manufacturing network (mammalian, bacterial, sterile filling) to serve glp-1 and other high-growth biologics
The complexity of DPP4 action stems from (i) a long list of substrates cleaved by the enzyme including hormones, growth factors, and cytokines, (ii) an additional function of this protein being a binding partner at the surface of different cells, specifically immune cells, and (iii) the recent discovery that DPP4 is an adipokine with different endocrine functions
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