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Based on current clinical trial data, tirzepatide (Zepbound/Mounjaro) at the 15 mg dose produces the highest average weight loss approximately 2022% of body weight, or around 48 lbs on average in the SURMOUNT-1 trial
GLP-1 receptor agonists reduce appetite and food intake, potentially leading to micronutrient deficiencies rather than causing direct malabsorption
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