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However, GLP-1RAs markedly reduced postprandial increases in triglycerides, apolipoprotein (Apo)B48 (major structural protein of chylomicrons), and ApoC-III (key regulator of triglyceride-rich lipoprotein metabolism), independently of gastric emptying [38,39,40]

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In laboratory studies, researchers often use adipocyte cell cultures and animal models to analyze how incretin receptor activation influences molecular pathways involved in lipid metabolism

That comes out to an average of about 27 pounds, compared with about 2 pounds for patients on a placebo