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The UK MHRA has issued a specific safety warning that GLP-1 and dual GIP/GLP-1 medications are not substitutes for insulin

The p-values are all less than 0.0001, which at this sample size is just shorthand for the result being real

Sermorelin, acting on GHRH-R expressed primarily on somatotrophs, is also physiologically selective and does not significantly stimulate cortisol or prolactin at therapeutic doses

A number of underlying mechanisms have been proposed, including increased oxidative stress, disruption of normal hormonal and neurological signaling, impaired cellular and mitochondrial processes, formation of abnormal proteins, and DNA damage