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And so, GLP-1 receptor agonists improve blood glucose control directly by promoting insulin secretion and indirectly by facilitating weight loss

Diabetes Therapy 15(8):17491768 Volpe S, Lisco G, Fanelli M, Racaniello D, Colaianni V, Lavarra V, Triggiani D, Crudele L, Triggiani V, Sabb C (2023) Oral semaglutide improves body composition and preserves lean mass in patients with type 2 diabetes: a 26-week prospective real-life study

doi: 10.3389/fimmu.2018.02737 49 ParryRVChemnitzJMFrauwirthKALanfrancoARBraunsteinIKobayashiSVet al

demonstrated that GABA (1.5 gr/kg/day, IP) normalized hyperglycemia, improved insulin sensitivity (measured by insulin clamp), reduced liver glucagon receptor mRNA (but not glucagon levels), and increased muscle GLUT4 translocation to plasma membrane as well as GLUT4 mRNA expression ( i.p