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ICH Q6A: SpecificationsTest Procedures and Acceptance Criteria for New Drug Substances and New Drug Products

Remove any air bubbles by tapping the syringe barrel and pushing the plunger slightly until a tiny drop appears at the needle tip

So, the key point here is not necessarily that GLP-1 drugs are harmful to bones on their own, but rather that the weight loss they induce could increase the risk of osteoporosis, particularly if not managed carefully