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A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity

While the heightened lifetime risk of PDAC in pancreatogenic diabetes raises the possibility that earlier or more frequent surveillance could improve outcomes, such an approach currently exceeds existing guideline recommendations and would require formal evaluation of cost-effectiveness, diagnostic yield, and patient-centered outcomes before broad implementation

This is especially true during perimenopause, when shifting hormone levels can influence how your body responds to treatment

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