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The mechanism is mechanical: slowed transit time allows colonic bacteria to ferment undigested carbohydrates longer, producing excess gas (methane and hydrogen)

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FIGURE 1 3.2 FOXO4-DRI effectively improves vascular function in prematurely aging mice To further explore the role of FOXO4-DRI in aged mice, we constructed prematurely aging mouse model by administering D-galactose (200 mg/kg) intraperitoneally for 8 weeks