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In one study, the administration of IGF-1 to rats with diabetic cardiomyopathy produced several beneficial effects, including a reduction in myocardial apoptosis, oxidative stress, inflammation, interstitial fibrosis, and metabolic irregularities
Pharmacol Rev (2008) 60:470512
Thorax 55 , 167169 (2000)
Additionally, sex-specific effects remain underexplored, as evidence suggests differential susceptibility to Epstein-Barr virus-driven AD in females 25 , and metformin has been reported to exert sex-specific effects on cognition, which may interact with DM2 DMTs in influencing AD risk
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