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Histamine sensitivity may cause mild symptoms, while histamine intolerance often involves more systemic, ongoing reactions, especially after eating high-histamine foods
The reduction of cardiovascular events is not only related to anti-diabetic properties, but also to pleotropic effects leading to the reduction of the residual cardiovascular risk, that has been defined as the risk of progression of CV events (MACE or HF) that remains after the optimal glycaemic control in T2DM patients, and it seems to be related to meta-inflammation, defined as a low-grade chronic and sterile inflammatory status
The injection pen delivery system may improve adherence compared to traditional vial-and-syringe methods
