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Tirzepatide has an additional, lower-frequency side effect dysesthesia (unusual sensations) linked to GIP receptor activity

In particular, fracture risk should be evaluated in populations at risk of fracture, such as postmenopausal women and men older than 50 years

Weight loss typically begins in this phase, averaging 1 to 3 pounds per week for most patients, though individual results vary significantly based on starting weight, diet quality, and activity level