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However, in states of leptin resistance such as obesity, this regulatory mechanism may be impaired (102, 103)
Retatrutide is a triple receptor agonist targeting GLP-1, GIP, and glucagon receptors a mechanism distinct from semaglutide and tirzepatide
By increasing feelings of fullness and slowing stomach emptying, Semaglutide helps reduce overall calorie intake
Clinical data from the SURMOUNT trials demonstrated that tirzepatide delivers weight reductions between 20-21% at the highest therapeutic dose, significantly outperforming older GLP-1-only treatments
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