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Owing to insidious symptoms and the lack of highly sensitive and specific biomarkers, the diagnosis of precancerous or cancerous esophageal lesions is primarily based on endoscope-based pathologic changes, which are expensive, painful, and often cause late diagnosis

If taking it in the morning, do so on an empty stomach with 8 ounces of water

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On the other hand, GPR65-expressing vagal afferents form mucosal endings in duodenal villi, such that they are selectively activated by duodenal infusion of nutrients [32]