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are there GLP-1 receptors in the circulatory system
Their blood sugar effects are substantial: Semaglutide: Reduces A1c by 1.5-1.8% from baseline (Ozempic trials) Tirzepatide: Reduces A1c by 2.0-2.3% from baseline (SURPASS trials)
Researchers studying gastrointestinal effects have used both acute (single-dose) and chronic (7-14 day) protocols, with efficacy observed in both paradigms
APC, antigen presenting cell
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