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553 Luo, Y
Similar recommendations were made by the European Medicines Agency (EMA) that required including major adverse cardiovascular events (MACE) as a primary endpoint ( These regulatory requirements led to the discovery of cardiovascular benefits in GLP-1R agonists, demonstrating the importance of due diligence and proactive safety monitoring
CSF levels of GABA, glutamate, threonine, glycine, taurine, histidine, and 3-methoxytyrosine were decreased
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